Know Labs’ non-invasive glucose monitor achieves 11.1% MARD in first study
including participants with diabetes and venous blood as a comparative reference.
Results presented at ATTD. See press release HERE.
Clinical Research &
Development
Know Labs is progressing on the path to FDA submission for clearance as a medical device. As we prioritize external validation of our technology and transparency in our progress, we are continuously adding to a growing body of evidence.
March 6, 2024
Clinical study among people with prediabetes and T2 diabetes using venous blood as comparative reference.
A study titled, “Non-Invasive Blood Glucose Monitoring in People with Diabetes Using an RF Sensor and Venous Blood Comparator,” assesses the accuracy of the novel Know Labs radiofrequency (RF) dielectric sensor for non-invasive blood glucose measurement in participants with prediabetes and Type 2 diabetes using venous blood as comparative reference. Results were presented as e-Poster at the 17th International Conference on Advanced Technologies and Treatments for Diabetes.
Reviewed by: Advanced Technologies & Treatments for Diabetes
Klyve D, Anderson JH, Currie K, Ward C, Pandya K, Somers V. Published March 6, 2024. Non-Invasive Blood Glucose Monitoring in People with Diabetes Using an RF Sensor and Venous Blood Comparator. The 17th International Conference on Advanced Technologies and Treatments for Diabetes, Florence, IT.
July 26, 2023
Novel Data Preprocessing Techniques in an Expanded Dataset Improve Machine Learning Model Accuracy
A study titled, “Novel Data Preprocessing Techniques in an Expanded Dataset Improve Machine Learning Model Accuracy for a Non-Invasive Blood Glucose Monitor,” validates the stability of a machine learning model on an expanded dataset.
Reviewed By: American Physiological Society
Klyve D, Pandya K, Ward C, Shelton B. Novel Data Preprocessing Techniques in an Expanded Dataset Improve Machine Learning Model Accuracy for a Non-Invasive Blood Glucose Monitor. Published online July 26, 2023
May 30, 2023
Algorithm Refinement In The Non-Invasive Detection of Blood Glucose
A study titled, “Algorithm Refinement in the Non-Invasive Detection of Blood Glucose Using Know Labs' Bio-RFID Technology,” demonstrates an ML model and other data science techniques improved the accuracy of Bio-RFID for predicting blood glucose, using the Dexcom G6® as reference device.
Peer Reviewed By: Members of Know Labs' Scientific Advisory Board
Klyve D, Currie K, Anderson JH, Ward C, Schwarz D, Shelton B. Algorithm Refinement in the Non-Invasive Detection of Blood Glucose via Bio-RFIDTM Technology. Published online July 6, 2023:2023.05.25.23290539. doi:10.1101/2023.05.25.23290539
May 5, 2023
Technical Feasibility Clinical Study
A study titled, “Technical Feasibility of a Novel Sensor for Non-Invasive Blood Glucose Monitoring Compared to Dexcom G6®,” demonstrates that the Bio-RFID sensor can deliver stable, repeatable results in predicting blood glucose concentrations using the Dexcom G6® as a reference device. Results were presented at American Association of Clinical Endocrinology (AACE) 2023 Annual Meeting.
Peer Reviewed By: American Association of Clinical Endocrinology
Klyve D, Shelton B, Ward C, Schwarz D, Anderson JH, Kent S. Published May 5, 2023. Technical Feasibility of a Novel Sensor for Non-Invasive Blood Glucose Monitoring Compared to Dexcom G6®. American Association of Clinical Endocrinology, Seattle, WA.
April 21, 2023
Proof of Principle Study in Collaboration with Mayo Clinic
A study titled, “Detecting Unique Analyte-Specific Radio Frequency Spectral Responses in Liquid Solutions – Implications for Non-Invasive Physiologic Monitoring,” was conducted in collaboration with Mayo Clinic and demonstrates the accuracy of Know Labs’ non-invasive Bio-RFID technology in quantifying different analytes in vitro. Results were presented at the American Physiological Society 2023 Summit.
Peer Reviewed By: Sensors Journal & American Physiology Society
Klyve D, Anderson JH, Lorentz G, Somers VK. Detecting Unique Analyte-Specific Radio Frequency Spectral Responses in Liquid Solutions—Implications for Non-Invasive Physiologic Monitoring. Sensors. 2023;23(10):4817. doi:10.3390/s23104817
February 28, 2023
Proof of Concept Clinical Study
This technical report titled, "Non-Invasive Blood Glucose Monitoring: A Validation of a Novel Sensor Compared to a Dexcom G6®," presents proof of concept for a new method to quantify blood glucose levels (BGL) in vivo non-invasively using RF methods by means of training a model to predict readings of the Dexcom G6®, as a proxy for BGL. The method uses a new type of sensing device that rapidly scans a wide band of RF frequencies. The report outlines data science techniques used to train a neural network model to make predictions, and includes metrics of model success and future directions of this work.
Peer Reviewed By: Members of Know Labs' Scientific Advisory Board
Klyve D, Shelton B, Lowe S, Ward C, Schwarz D, Kent S. Non-Invasive Blood Glucose Monitoring: A Validation of a Novel Sensor Compared to a Dexcom G6. Published online February 28, 2023.